and
FDA = Food and Drug Administration, H2RA = histamine-2 receptor antagonist, PPI = proton pump inhibitor
Pantoprazole absorption is not affected by concomitant administration of antacids
1 Usually, heartburn during pregnancy resolves soon after delivery, however, sometimes it represents exacerbation of pre-existing gastro-oesophageal reflux disease
there was no significant increase in major birth defects during analysis of first trimester exposure to pantoprazole in 549 live births
A lot happens for you in the first trimester
Pantoprazole undergoes little first-pass metabolism, resulting in an absolute bioavailability of approximately 77%
The mean pantoprazole concentration in breastmilk was 62 mcg/L on day 1 and 153 mcg/L on day 7
According to a study of 510 pregnant women, approximately 26% have GERD symptoms during the first trimester
Omeprazole Pregnancy Warnings
In the first trimester of pregnancy, basal lower oesophageal sphincter (LES) Pantoprazole is categorized as FDA class B
45] and for spontaneous abortions
Discontinue pantoprazole sodium at the first signs or symptoms of severe cutaneous adverse reactions or other signs of hypersensitivity and consider further evaluation
Fingers have begun to form